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Blood sampling for infection is not only based on white blood cells, but this indicator can also be used as a reference. Too high means serious

 Some netizens consulted: I have a cold and fever. It is usually hot at night, but during the day. I went to the hospital for a blood test. They said that the interleukin 6 is high. What is the reason for the high interleukin 6? has no meaning?


Interleukin 6 (IL-6) is a kind of cytokine, belongs to the peptide substance, is a kind of interleukin (a total of 29 kinds), composed of fibroblasts, B lymphocytes, T lymphocytes, macrophages, epithelial cells And a variety of tumor cells are produced and released into the blood. Interleukin 6 plays an important role in maintaining the body's immune response, bone marrow hematopoiesis and inflammation. Under normal circumstances, the content of interleukin 6 in the body is minimal. However, when the body is infected by microorganisms and inflammation occurs, the immune system is activated and interleukin 6 will increase. The increase of interleukin 6 is positively correlated with inflammation. The more severe the inflammation, the higher the interleukin 6 will be. Especially in bacterial infections, the elevated levels of IL-6 are significantly higher than non-bacterial infections.

As early as 2015, "Nosocomial Infection Management Quality Control Indicators" clearly stipulated that the pathogenic detection indicators before antibiotic treatment should include procalcitonin PCT, IL-6 and other indicators. In the early stage of acute infection, IL-6 will rise, the rise of IL-6 is earlier than C-reactive protein (CRP) and procalcitonin (PCT), and it lasts for a long time. After bacterial infection, IL-6 levels increase rapidly and reach a peak within 2 hours. When IL-61 000 pg/ml often indicates poor prognosis.


Is the increase in IL-6 necessarily a bacterial infection?

Not necessarily. Interleukin 6 is involved in the occurrence and development of many diseases, and its level is related to body inflammation, viral infection, autoimmune diseases, malignant tumors, post-transplant rejection, traumatic brain injury, cardiovascular and cerebrovascular diseases, liver cirrhosis, and renal insufficiency. And so on are equally relevant. Therefore, IL-6 may also increase during the acute phase of these diseases.


Autoimmune diseases, such as rheumatoid arthritis, psoriatic arthritis, and compulsive spondylitis, patients will have excess IL-6 in the blood and joints. The new drug tocilizumab is an IL-6 inhibitor. The use of tocilizumab can reduce inflammation, reduce symptoms, reduce joint damage, and improve the quality of life.

The cellular immune function of tumor patients is closely related to the occurrence and development of tumors. When tumor cells proliferate, infiltrate or metastasize, they secrete more endogenous IL-6. Increased levels of IL-6 may indicate the deterioration of patients with malignant tumors, and have certain reference value for evaluating the prognosis of patients.

For people with common upper respiratory tract diseases, if IL-6 is elevated, it may indicate bacterial infection, but it is generally combined with clinical symptoms, blood routine, C-reactive protein, procalcitonin and other comprehensive judgments to guide the use of antibiotics.

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